In 2009 Frankfurt Airport was the third busiest airport in Europe in terms of total passenger traffic but it was second behind Charles de Gaulle in terms of plane movements and in terms of cargo traffic.

Busiest routes at Frankfurt Airport (2009) Rank Airport departing Passengers Airlines
1 Berlin-Tegel 777,900 Lufthansa, Air Berlin
2 Hamburg 606,700 Lufthansa, Air Berlin
3 London-Heathrow 602,300 British Airways, Lufthansa
4 Munich 488,700 Lufthansa
5 Chicago-O'Hare 453,900 Air India, American Airlines, Lufthansa, United Airlines
6 Madrid 453,800 Iberia, LAN Airlines, Lufthansa
7 Paris-Charles de Gaulle 445,500 Air France, Lufthansa
8 Vienna 440,000 Adria Airways, Austrian Airlines, Lufthansa, Niki
9 Singapore 427,400 Lufthansa, Qantas, Singapore Airlines
10 New York-JFK 353,200 Delta, Lufthansa, Singapore Airlines
11 Washington-Dulles 336,800 Lufthansa, United
12 Bangkok-Suvarnabhumi 335,800 Lufthansa, Thai Airways
13 Istanbul-Atatürk 330,100 Lufthansa, Turkish Airlines
14 Rome-Fiumicino 321,200 Alitalia, Ethiopian Airlines, Lufthansa, Yemenia
15 Dubai 318,300 Condor, Emirates, Lufthansa
16 Barcelona 297,300 Lufthansa
17 Palma de Mallorca 296,000 Air Berlin, Condor, TUIfly
18 Toronto-Pearson 290,200 Air Canada, Air Transat, Lufthansa
19 San Francisco 284,300 Lufthansa, United
20 Amsterdam 279,700 KLM, Lufthansa
21 Zurich 278,300 Lufthansa, Swiss International Air Lines
22 Copenhagen 270,000 Lufthansa, SAS
23 Tokyo-Narita 265,400 All Nippon Airways, Japan Airlines, Lufthansa
24 Stockholm-Arlanda 257,600 Lufthansa, SAS
25 Beijing-Capital 249,600 Air China, Lufthansa
26 Antalya 245,600 Condor, Pegasus Airlines, Sky Airlines, SunExpress, TUIFly
27 Lisbon 244,300 Lufthansa, TAP Portugal
28 Shanghai-Pudong 239,200 Air China, China Eastern Airlines, Lufthansa
29 Seoul-Incheon 238,500 Asiana Airlines, Korean Air, Lufthansa
30 Athens 237,600 Aegean Airlines, Lufthansa, Olympic Airlines
31 Newark 232,300 Air India, Continental, Lufthansa
32 Hong Kong 231,300 Cathay Pacific, Lufthansa
33 Oslo-Gardermoen 222,600 Lufthansa, SAS
34 São Paulo-Guarulhos 220,315 Lufthansa, TAM Airlines
35 Tel Aviv 219,000 El Al, Lufthansa, Sun d'Or International Airlines
36 Helsinki 218,200 Finnair, Lufthansa
37 Brussels-National 216,200 Brussels Airlines, Lufthansa
38 Prague 206,200 Czech Airlines, Lufthansa
39 Johannesburg 205,755 Lufthansa, South African Airways
40 Moscow-Domodedovo 201,500 Lufthansa, S7 Airlines, Transaero